George Noory served nine years in the United States Navy. He has said that he became fascinated with ufology and the paranormal as a child after having an out-of-body experience. As a teenager, George joined NICAP, the UFO organization that was a precursor to today's MUFON.

Prior to hosting Coast to Coast AM, he hosted his own late-night radio program on KTRS in St. Louis where he was known as "the Nighthawk." The show, like Coast-to-Coast, also dealt with the paranormal, and was carried by stations in five states.

Noory became a guest host for Coast-to-Coast before replacing Ian Punnett as the Sunday night host. On January 1st, 2003, Noory took over the weeknight hosting duties from Art Bell, who had decided again to retire. Bell then returned to host the last two Sundays of each month, with Ian Punnett doing the Saturday night shows. With Noory as host, Coast to Coast AM experienced a continuous boost in listenership and became the top rated late night radio talk show in numerous radio markets throughout the country.

On January 21, 2006, it was announced that Art would return to Coast to Coast on Saturdays and Sundays, replacing Ian Punnett on Saturdays, and George Noory on the first two Sundays of the month. Art returned to the airwaves on January 22, 2006, following his wife's death on January 5. Art announced on his first show back on January 22 that Ian Punnett will not be unemployed. Ian will work the prefeed live for 4 hours before Art Bell's slot on Saturday nights from 9pm-1am EST, 6pm-10pm PST.

Noory is known for his mild-mannered interviewing style and his willingness to air callers with claims of alien abductions, near-death experiences, and other paranormal topics. In the past, he has made some unusual claims on his show. For example, on his March 10-11, 2006 show, he claimed that he was reincarnated in the 22nd century as Dexter Monterrey, a time traveller that hosted the last hour of Coast to Coast that night. He has also claimed that when he broadcasts his show from St. Louis, he broadcasts from a dark cave in the middle of nowhere. Regular listeners who are familiar with the show assert that this is Noory's tongue-in-cheek sense of humor; however, he often makes such claims in a deadpan manner that makes it difficult to determine if he is serious.

George Noory has repeatedly announced on-air that he is committed to remaining the major host of "Coast" until at least 2012, which is a frequently discussed year in regard to Earth changes. His commitment is substantiated by a long-term contract with Premiere Radio.