Dorian Gregory began his acting career with guest roles in various series. He was seen in Baywatch, Beverly Hills 90210, Sister, Sister, and others. He played his first major role in Baywatch Nights, where he belonged to the regular cast from 1996 to 1997.

In 1998 Dorian Gregory received the role of the policeman Darryl Morris in the successful series Charmed, which he played until 2005.

Privately, Dorian is an active humanitarian, involved in the Jeopardy Program, sponsored by the Los Angeles Police Department for youth at risk, as well as serving as the National Spokesman for the American Diabetes Association. He was diagnosed with the disease when he was nine, and now talks to young adults and children on the subject as a motivational speaker. Dorian is working to raise funds to help find a cure for diabetes and offering information to support people living with the disease. Furthermore, Dorian is actively involved with AIDS Project LA and for the organisation Mothers Against Drunk Driving.

Dorian has hosted several events like BET Anniversary and Achievement Awards with Debbie Allen and Shirley Moore, Black Stuntwomen Beach Competition, and Elite Lee Jeans Model Look with Roshumba and Angelica Brideges. He has also hosted a radio show on Black Writers, supports minority Film Makers, appeared at high school dedication to support better educational opportunities and been a guest in many charitable activities and parades. He is one of the founding members of the Epiphany Theater Group, established by writer/producer/director Bill Duke. He still performs with a live sketch comedy troupe directed by his sister Mercedes.